Am. 8, 143–151. 61, 7315–7324. Molecules 12 (20), 22329–22340. Trends Mol. JC and KT: Concept, design, literature search and manuscript review. These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. doi:10.1021/jf200371r, Du, C. Y., Choi, R. C., Zheng, K. Y., Dong, T. T., Lau, D. T., and Tsim, K. W. K. (2013). Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. doi:10.1097/00043426-199124000-00002PubMed Abstract, Awad, D. S., Ali, R. M., Mhaidat, N. M., and Shotar, A. M. (2014). In addition, Xu et al. | (* Significant with respect to MMS. doi:10.1016/j.foodres.2006.05.006, Zhao, Z., Liu, M., and Tu, P. (2008). Actually jujube … (2020). Jujubes are also commonly called red dates, Chinese dates, Korean dates or Indian dates. Toxicol. (B) The composition in monosaccharide purified from jujube. Jujube is a functional food, which is believed to possess robust effect in tonifying the blood, in order to prevent blood deficiency in human. Nur noch 1 auf Lager. Eaten either fresh, candied, canned, or … The genotoxic activity of MMS was inhibited in a dose - related manner by BA. J. Agric. Immunol. HPLC-DAD chromatogram and quantification of…, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in Ziziphus jujuba fruit extract…, Antioxidant activity of Ziziphus jujuba…, Antioxidant activity of Ziziphus jujuba fruit extract (ZFE): ZFE-1 (100% ethanol), ZFE-2 (75%…, Cytotoxicity and genotoxicity of Ziziphus…, Cytotoxicity and genotoxicity of Ziziphus jujuba fruit extract (ZFE) and betulinic acid (BA)…, A. Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. 103, 454–460. 3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response. Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). 48, 639–643. Effect of Fructus Jujubae polysaccharide on hemogram indexes and activity of ATPase in erythrocyte of rats with blood deficiency. Although the common names are red date and Korean date, the scientific classification of jujube is Ziziphus jujuba. Our evidence-based analysis on ziziphus jujuba features 56 … Exp. Schuster, S. J., Badiavas, E. V., Costa-Giomi, P., Weinmann, R., Erslev, A. J., and Caro, J. Food Sci. (2017). Free iron is released to blood circulation by ferroportin and further carried to bone marrow (Kovtunovych et al., 2010). As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response.
Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. 73, 2503–2513. Jeong and Kim (2019) investigated the effect of jujube and chokeberry diet in high-fat and high-fructose diet-induced dyslipidemia in animal studies. Hematol. Jujube extract stimulated the expression of HIF-1α mRNA, and the induced expression was demonstrated to be in a dose-dependent manner, having the highest effect by ∼80% of increase. The occurrence of renal interstitial fibrosis is accompanied by decrease of fibroblasts, which impairs the production of EPO. Front. In addition, jujube was reported to contain numerous minerals, e.g., iron and vitamin. 59, 6594–6604. Canada CA2707192A1, Choi, S. H., Ahn, J. fruits are nutritionally rich and have a broad spectrum of health benefits. Food Chem. that belongs to Rhamnaceae family. Nutr Cancer 72, 120–132. The dietary nutrient facts of main ingredients in fresh and dried jujubes are summarized in Supplementary Table S1, which provides an appropriate recommendation for selection of different forms of jujube for certain health benefits. Toxicol. (2018) reported protective effect of jujube extract on hypertensive rats. In human endothelial cells treated with betulinic acid, the endothelial nitric oxide synthase expression and nitric oxide production were robustly increased (Steinkamp-Fenske et al., 2007). 28, 1527–1532. 67, 1284–1291. Food Chem. B., Kozukue, N., Levin, C. E., and Friedman, M. (2011). Thus, jujube is considered as a popular nutritious food, worldwide (Li et al., 2007; San and Yildirim, 2010; USDA, 2012; Guo et al., 2013; Reche et al., 2019). The plant is self-fertile.
J. Biol. 115, 49–62. Nrf2-Keap1 defines a physiologically important stress response mechanism. Jujube is typically a small shrub or tree with small yellowish-green petals and drupe fruits that are about the size of a date and range from brown to purplish-black. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) 61, 3351–3363. A., Zhang, Y., Qian, D., Tang, Y., Zhu, Z., et al. Blood 116, 6054–6062. doi:10.1016/j.jchromb.2015.09.021, Li, B., Wang, L., Liu, Y., Chen, Y., Zhang, Z., and Zhang, J. doi:10.1111/j.1750-3841.2012.02946.x, Gao, Q. T., Cheung, J. K., Li, J., Jiang, Z. Y., Chu, G. K., and Duan, R. (2007). Xu, Y., Tao, Z., Jin, Y., Yuan, Y., Dong, T., and Tsim, K. W. K. (2018). Dordrecht, the Netherlands: Springer Science+Business Media. Food Chem. Similarly, the protein level of HIF-1α was markedly up regulated at the treatment of 10 μM quercetin (Nishimura et al., 2017). The intake of jujube extracts at concentrations of 150 and 250 mg/kg/day significantly stimulated thymus and spleen indices in mice, which indicated obviously strengthening the non-specific immunity in jujube-treated mice (Li et al., 2011). doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. Erythrophagocytosis is a process, where the senescent RBCs are phagocytosed by macrophage (Klei et al., 2017). Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. Released to blood circulation by ferroportin and further carried to bone marrow ( Kovtunovych al.... Persia, jujube has a vital role in controlling pro-inflammatory cytokine expression in effect. Gzt stimulated the transcriptional activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage its! 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