Am. 8, 143–151. 61, 7315–7324. Molecules 12 (20), 22329–22340. Trends Mol. JC and KT: Concept, design, literature search and manuscript review. These results support the effect of jujube on HIF-1α expression in both mRNA and protein levels. doi:10.1021/jf200371r, Du, C. Y., Choi, R. C., Zheng, K. Y., Dong, T. T., Lau, D. T., and Tsim, K. W. K. (2013). Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. doi:10.1097/00043426-199124000-00002PubMed Abstract, Awad, D. S., Ali, R. M., Mhaidat, N. M., and Shotar, A. M. (2014). In addition, Xu et al.  |  (* Significant with respect to MMS. doi:10.1016/j.foodres.2006.05.006, Zhao, Z., Liu, M., and Tu, P. (2008). Actually jujube … (2020). Jujubes are also commonly called red dates, Chinese dates, Korean dates or Indian dates. Toxicol. (B) The composition in monosaccharide purified from jujube. Jujube is a functional food, which is believed to possess robust effect in tonifying the blood, in order to prevent blood deficiency in human. Nur noch 1 auf Lager. Eaten either fresh, candied, canned, or … The genotoxic activity of MMS was inhibited in a dose - related manner by BA. J. Agric. Immunol. HPLC-DAD chromatogram and quantification of…, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in Ziziphus jujuba fruit extract…, Antioxidant activity of Ziziphus jujuba…, Antioxidant activity of Ziziphus jujuba fruit extract (ZFE): ZFE-1 (100% ethanol), ZFE-2 (75%…, Cytotoxicity and genotoxicity of Ziziphus…, Cytotoxicity and genotoxicity of Ziziphus jujuba fruit extract (ZFE) and betulinic acid (BA)…, A. Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. 103, 454–460. 3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response. Thus, the function of jujube in promoting EPO expression in renal anemia patients was in line to that of Jian-Pi-Yi-Shen (Chen et al., 2019). 48, 639–643. Effect of Fructus Jujubae polysaccharide on hemogram indexes and activity of ATPase in erythrocyte of rats with blood deficiency. Although the common names are red date and Korean date, the scientific classification of jujube is Ziziphus jujuba. Our evidence-based analysis on ziziphus jujuba features 56 … Exp. Schuster, S. J., Badiavas, E. V., Costa-Giomi, P., Weinmann, R., Erslev, A. J., and Caro, J. Food Sci. (2017). Free iron is released to blood circulation by ferroportin and further carried to bone marrow (Kovtunovych et al., 2010). As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. BMC Compl. 23, 706–710. The jujube extract at various concentrations (0.75–3 mg/ml) was applied onto cultured Hep3B cells for 6 h, and then total RNA was harvested from the cultures for PCR analysis. jinsixiaozao and its property. Biochem. Mitsuhashi, Y., Furusawa, Y., Aradate, T., Zhao, Q. L., Moniruzzaman, R., and Kanamori, M. (2017). Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. Trad. Ebrahimimd, S., Ashkani-Esfahani, S., and Poormahmudibs, A. doi:10.1016/j.jep.2019.01.027 | PubMed Abstract, Steinkamp-Fenske, K., Bollinger, L., Xu, H., Yao, Y., Horke, S., and Förstermann, U. Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial. Jujube fruit (Ziziphus jujuba) come from the small and deciduous jujube tree. (2014). Food Chem. Creative Commons Attribution License (CC BY). The jujube (Ziziphus jujuba Mill.) Med. doi:10.1002/ptr.5160, Chen, J., Lam, C. T., Kong, A. Y., Zhang, W. L., Zhan, J. Y. X., Bi, C. W. C., et al. (2016). J. Agric. 2016;50:144–158. Fatty acid profile of peel and pulp of Spanish jujube (Ziziphus jujuba Mill.) The study revealed that jujube extract markedly declined granuloma tissue formation, as compared with model rat. doi: 10.1515/jbcpp-2019-0172. Jujuboside B from jujube markedly inhibited platelet aggregation, and which was considered as one of the active ingredients in processing anti-platelet effect (Seo et al., 2013). Erythropoiesis is considered to play critical roles in hematopoiesis, by which production of red blood cells (RBCs) is occurred. J. Biol. Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea. According to the theory of TCM, blood deficiency shows similarity to anemia of individual in western medicine (Shi et al., 2019). Life Sci. 277, 238–245. Plant extracts rich in aforesaid flavonoids are considered, therefore, potentially useful as therapeutic agents for anemia. (2014c) found that jujube extract (2 mg/ml) induced CREB phosphorylation in cultured cells, and this effect was fully blocked by H89, a cyclic AMP-dependent protein kinase A inhibitor. The reduction at 60% was observed under the pre-treatment of extract at 3 mg/ml (Chen et al., 2014a). (2012). Jujube is not only consumed as daily food, but also prescribed as a tonic TCM for blood nourishment in a formulated decoction. doi:10.1002/ptr.5796, Yoo, S. R., Kim, Y., Lee, M. Y., Kim, O. S., Seo, C. S., Shin, H.-K., et al. (2003). Heme oxygenase-1 (HO-1) has a vital role in metabolizing heme to biliverdin, carbon monoxide and free iron. Besides, jujuboside and flavonoid in the fruit were also proposed to be active compounds, and which might responsible for anti-inflammatory effects (Goyal et al., 2011). In parallel, puerarin was identified in the seeds of jujube (Cheng et al., 2000). COVID-19 is an emerging, rapidly evolving situation. This site needs JavaScript to work properly. J. Experi. (2019). 66, 7616–7626. GZT belongs to exterior-releasing formula that is able to dispel pathogenic factors from superficies of body, and the effect of jujube within this formula is believed to tonify “Qi” and to replenish “Blood” of the body resulting from corresponding pathological changes. J. Pharmacol. The jujube (Ziziphus jujuba Mill.) TABLE 2. Med. In support of this notion, Almeer et al. 2018;836:72–78. An acetate switch regulates stress erythropoiesis. Triterpenic acids have been isolated and purified from jujube, including ceanothenic acid, zizyberanal acid, zizyberenalic acid, zizyberanalic acid, and ceanothic acid (Figures 3C) (Yu et al., 2012). Still in the theme of health benefits, now we will talk about health benefits of jujube fruit. One-sixth of prescriptions described in this ancient classic book contain jujube, in which jujube is commonly served as assistant or courier medicinal herb with a herbal formulated decoction, according to the theory of TCM. 226, 985–989. The one-inch-long green fruits ripen to dark red and finally black. The extract of Ziziphus jujuba fruit (jujube) induces expression of erythropoietin via hypoxia-inducible factor-1alpha in cultured Hep3B cells. The name Ziziphus is related to an Arabic word and ancient Greeks used the word ziziphon for the jujube. Med. 48, 1350–1354. Antiasthmatic potential of Zizyphus jujuba Mill. (2007). Here, the potential effects of jujube on erythrophagocytosis were summarized (Figure 4). Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia. It is hardy to zone (UK) 6. (2016) reported that the intake of jujube extract showed an improvement in iron deficiency anemia rats. The polysaccharides extracted from jujube usually consist of five monosaccharides, i.e., galactose, arabinose, rhamnose, glucose and xylose (Zhao et al., 2008) (Figures 3B). Front. Nephrol. J. Agric. Feng et al. Nat. doi:10.1016/j.fct.2010.02.036, Yu, L., Jiang, B. P., Luo, D., Shen, X. C., Guo, S., Duan, J. EPO gene expression regulates primarily at the level of transcription, and which is further controlled by a number of transcriptional and post-transcriptional factors (Schuster et al., 1989; Goldberg et al., 1991). Rapid determination of amino acids in fruits of Ziziphus jujuba by hydrophilic interaction ultra-high-performance liquid chromatography coupled with triple-quadrupole mass spectrometry. 13, 376–387. The jujube is a drupe or stone fruit. Food Chem. 581, 5087–5093. J. Chromatogr. fruit: a review of current knowledge of fruit composition and health benefits. Contents changes of triterpenic acids, nucleosides, nucleobases, and saccharides in jujube (Ziziphus jujuba) fruit during the drying and steaming process. Digestion 78, 224–228. 8, 73. doi:10.3389/fimmu.2017.00073 | PubMed Abstract, Kovtunovych, G., Eckhaus, M. A., Ghosh, M. C., Ollivierre-Wilson, H., and Rouault, T. A. The potential active ingredients relating to the activities of jujube are summarized. 31, 456–468. Biomed. Sinha S., Biswas D., Mukherjee A. Antigenotoxic and antioxidant activities of palmarosa and citronella essential oils. Motohashi, H., and Yamamoto, M. (2004). Human lymphocytes were incubated with the Ziziphus fruit ethanol extracts (ZFE) or betulinic acid (BA) followed by an exposure to either 50 μM of MMS or 250 μM of H2O2. Zizyphus is a shrub or small tree. The activation by two folds was confirmed under application of jujube extract at 3.0 mg/ml (Chen J. et al., 2016). Clin. 77, C1218–C1225. Screening of a functional polysaccharide from Zizyphus jujuba cv. Formul. Pharmacol. Our evidence-based analysis on ziziphus jujuba … This assumption requires further studies as to confirm the ability of jujube to prevent/treat renal anemia through regulation of EPO production. Altern Ther Health Med. Li J.W., Fan L.P., Ding S.D., Ding X.L. Sci. 112, 858–862. doi:10.1021/jf104018u | PubMed Abstract, Zhu, R., Fan, Z., Dong, Y., Liu, M., Wang, L., and Pan, H. (2018). Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. J. Ethnopharmacol. Ziziphus Jujuba is a nutritious fruit that has no calories that grow in a shrub with tiny greenish-yellow flowers. 322, 836–842. Pharm. Erythropoietin: structure, control of production, and function. Flavonoids are common chemical presented in a wide range of plants. (2015). Technol. After 10 weeks of dietary treatment, jujube and chokeberry significantly ameliorated high-fat and high-fructose diet-induced dyslipidemia and improved insulin resistance (Jeong and Kim, 2019). 2007;103:454–460. doi:10.7150/ijbs.14059 | PubMed Abstract.  |  65, 514–518. (2010). In line with this, the applied jujube extract at 100–500 μg/ml inhibited nitric oxide production and splenocyte proliferation on the inflammatory activated cells (Yu et al., 2012). Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Soc. The water extract of immature jujube extract showed better activity in stimulating transcriptional activity of HRE than that of mature jujube (Chen et al., 2015). Haematologica 97, 994–1002. (2016). USDA nutrient database for standard reference. doi:10.1016/s0024-3205(03)00652-0, Lim, T. K. (2013). doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). In folk medicine, three pieces of jujube are recommended to be consumed daily, about 15 g of dried weight in total. Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. doi:10.5455/medarh.2013.67.156-160, San, B., and Yildirim, A. N. (2010). Med. doi:10.1055/s-0034-1383049 | PubMed Abstract, Chen, J., Maiwulanjiang, M., Lam, K. Y., Zhang, W. L., Zhan, J. Y., Lam, C. T. W., et al. Specific targets supporting the clinical usage of jujube in hematopoietic functions however remain unclear. Clinically, blood deficiency is usually encountered in women due to the loss of menstrual blood, or in patient who has lost blood or suffered from chronic malnutrition. Role Of Ziziphus Jujuba In Ancient Medicine Med. Compared with model group, the pre-treatment with jujube extract at different doses (100, 200, and 400 mg/kg/day) in colon of rats for 5 days by oral gavage significantly induced mRNA expressions of Nrf2 and HO-1, giving the highest response by seven and two folds, respectively (Almeer et al., 2018). Failure to up regulate the circulating EPO under hypoxia thereafter leads to anemia (Jelkmann, 1992). Hence, possible signaling pathways involved in jujube polysaccharide-treated in vitro or in vivo models are needed for further investigation. Furthermore, the authors described that jujube at various concentrations (30–200 μg/ml) showed a significant dose-dependent promotion of splenocyte proliferation, with the highest response at ∼100% increase. doi:10.1021/jf402379u | PubMed Abstract, Chen, J., Wang, F., Huang, S., Liu, X., Li, Z., Qi, A., et al. In addition, there are no known toxicity and drug interaction being reported clinically for consumption of jujube. USA.gov. The treatment with jujube extract slightly inhibited NF-κB activity. doi:10.1016/j.procbio.2005.03.005, Li, J., Fan, L., Ding, S., and Ding, X. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Thirugnanasampandan R, Ramya G, Bhuvaneswari G, Aravindh S, Vaishnavi S, Gogulramnath M. J Complement Integr Med. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material, Al-Reza, S. M., Yoon, J. I., Kim, H. J., Kim, J. S., and Kang, S. C. (2010). HHS Arab M, Khorashadizadeh M, Abotorabi Z, Zarban A. J Basic Clin Physiol Pharmacol. Am. Ziziphus jujuba Mill. 107.123356 | PubMed Abstract, USDA (2012). Food Res. Arch. doi:10.1681/ASN.2019020213PubMed Abstract, Chen, J., Chan, P. H., Lam, C. T., Li, Z., Lam, K. Y., Yao, P., et al. BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. These two fractions were found to dose-dependently induce proliferation of spleen lymphocyte, having the highest response under the treatment of jujube polysaccharide at 200 μg/ml. Food Chem. Xu, Y.-L., Miao, M.-S., Sun, Y.-H., and Miao, Y.-Y. Please enable it to take advantage of the complete set of features! Drug Targets 20, 108–115. (2016). Serum nitrite/nitrate level was notably up regulated in inflammatory rat; while pre-treatment with jujube significantly reduced the increased level of nitrite/nitrate (Goyal et al., 2011). (2016) investigated the inductive roles of GZT on EPO expression in cultures. 11:593655. doi: 10.3389/fphar.2020.593655. The hematopoietic functions of jujube. Erythropoietin. Biosci. Epub 2013 Mar 28. These acids possessed notable inhibitory activity on the activated inflammatory cells, and which could be one of the main ingredients in supporting the anti-inflammatory activity of jujube (Yu et al., 2012). About 0.48 mg iron and 69 mg vitamin C per 100 g of fresh fruit were reported (Li et al., 2007; USDA, 2012). (i) DNA damage measured as Tail DNA % in human lymphocytes exposed…, DNA damage measured as Tail DNA % induced by betulinic acid (BA) in…, Biochemical stress markers in liver cells of mice primed with betulinic acid (BA)…, Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and…, NLM (C) The chemical structures of varieties of triterpenic acids found in the fruit. In line with this, Ju-B-2, a molecular weight of over 2,000 kDa polysaccharide from jujube, was shown to have the immune activity. J. Agric. Betulinic acid, found in Zizyphi Spinosi Semen and jujube, possessed combined properties of inducing endothelial nitric oxide synthase and decreasing nicotinamide adenine dinucleotide phosphate oxidase. Comparison of antioxidant capacities of extracts from five cultivars of Chinese jujube. Yoo et al. Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. Jujube is usually called red date or Chinese date, which is the fruit of Ziziphus jujuba Mill. The pre-incubation of jujube extract (30, 100, and 300 mg/ml) for 5 min at 37°C in platelet-rich plasma was reported to suppress collagen (2 mg/ml)-, thrombin (0.4 U/ml)-, and arachidonic acid (100 mM)-induced aggregation of platelets (Seo et al., 2013). (2019). -. Planta Med. doi:10.1152/physrev.1992.72.2.449, Jeong, O., and Kim, H. S. (2019). The promoter of EPO gene contains HRE, and thus the activation of hypoxia-mediated signaling pathway is leading to activation of EPO expression (Post and Van Meir, 2001). 67, 156–159. Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay. doi:10.1021/jf5041564 | PubMed Abstract, Chen, J., Du, C. Y., Lam, K. Y., Zhang, W. L., Lam, C. T., Yan, A. L., et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. Here, the immune-modulatory properties of jujube under different scenarios are summarized (Figure 4). The arrow in red indicates the targets for jujube action. In addition, it has been reported that the content of bio-active ingredients, including nucleotide, flavonoid and polysaccharide, varied among different jujube cultivars (Chen et al., 2013), as indicated in Supplementary Table S2. Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. On the other hand, the intake of Jian-Pi-Yi-Shen, a Chinese herbal decoction comprising of Astragali Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Cistanches Herba, and other four herbs, was able to improve renal function and kidney injury in anemia rats suffering from chronic kidney disease (Chen et al., 2019). In spring, small clusters of yellow or white, fragrant blossoms appear, hidden in foliage between the leaf and stems. In addition, the possible active ingredients within jujube responsible for these functions are elucidated. Chin. Bioactive components in the fruits of Ziziphus jujuba Mill. (2011). 8, 1801–1807. jinsixiaozao Hort. doi:10.1016/j.foodchem.2006.08.016, Li, J., Shan, L., Liu, Y., Fan, L., and Ai, L. (2011). 1026, 254–262. B Analyt. doi:10.1016/j.febslet.2007.09.053 | PubMed Abstract, Goldberg, M. A., Gaut, C. C., Schapira, L., Antin, J. H., Ransil, B. J., and Antman, K. H. (1991). (2006). Based Complement. The fruits of Ziziphus jujuba, commonly known as jujube, red date or Chinese date, are taken as fresh or dried food, and as traditional medicine worldwide due to high nutritional and health values. Indeed, kaempferol and quercetin derivatives, including kaempferol 3-O-rutinoside, quercetin, quercetin 3-O-rutinoside, quercetin 3-O-galactoside and quercetin 3-O-β-D-glucoside (Figures 3A), were identified in jujube (Gao et al., 2012; Chen et al., 2013). Epilepsy Behav. FIGURE 3. Nutr. These results indicate that CREB-binding protein/HIF signaling can be involved in jujube-induced EPO production. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in, A. These studies however need further confirmation as no observation has been found in a physiology model of iron recycling. 39, 917–923. For instance, a cellular model of erythrophagocytosis using artificially-aged RBCs and macrophages may be designed to investigate mRNA and protein expressions of target enzymes relating to iron recycling. Against the inflammatory irritant action of Euphorbia plants. 4 Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. 73, 2503–2513. Jeong and Kim (2019) investigated the effect of jujube and chokeberry diet in high-fat and high-fructose diet-induced dyslipidemia in animal studies. Hematol. Jujube extract stimulated the expression of HIF-1α mRNA, and the induced expression was demonstrated to be in a dose-dependent manner, having the highest effect by ∼80% of increase. The occurrence of renal interstitial fibrosis is accompanied by decrease of fibroblasts, which impairs the production of EPO. Front. In addition, jujube was reported to contain numerous minerals, e.g., iron and vitamin. 59, 6594–6604. Canada CA2707192A1, Choi, S. H., Ahn, J. fruits are nutritionally rich and have a broad spectrum of health benefits. Food Chem. that belongs to Rhamnaceae family. Nutr Cancer 72, 120–132. The dietary nutrient facts of main ingredients in fresh and dried jujubes are summarized in Supplementary Table S1, which provides an appropriate recommendation for selection of different forms of jujube for certain health benefits. Toxicol. (2018) reported protective effect of jujube extract on hypertensive rats. In human endothelial cells treated with betulinic acid, the endothelial nitric oxide synthase expression and nitric oxide production were robustly increased (Steinkamp-Fenske et al., 2007). 28, 1527–1532. 67, 1284–1291. Food Chem. B., Kozukue, N., Levin, C. E., and Friedman, M. (2011). Thus, jujube is considered as a popular nutritious food, worldwide (Li et al., 2007; San and Yildirim, 2010; USDA, 2012; Guo et al., 2013; Reche et al., 2019). The plant is self-fertile. J. Biol. 115, 49–62. Nrf2-Keap1 defines a physiologically important stress response mechanism. Jujube is typically a small shrub or tree with small yellowish-green petals and drupe fruits that are about the size of a date and range from brown to purplish-black. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) 61, 3351–3363. A., Zhang, Y., Qian, D., Tang, Y., Zhu, Z., et al. Blood 116, 6054–6062. doi:10.1016/j.jchromb.2015.09.021, Li, B., Wang, L., Liu, Y., Chen, Y., Zhang, Z., and Zhang, J. doi:10.1111/j.1750-3841.2012.02946.x, Gao, Q. T., Cheung, J. K., Li, J., Jiang, Z. Y., Chu, G. K., and Duan, R. (2007). Xu, Y., Tao, Z., Jin, Y., Yuan, Y., Dong, T., and Tsim, K. W. K. (2018). Dordrecht, the Netherlands: Springer Science+Business Media. Food Chem. Similarly, the protein level of HIF-1α was markedly up regulated at the treatment of 10 μM quercetin (Nishimura et al., 2017). The intake of jujube extracts at concentrations of 150 and 250 mg/kg/day significantly stimulated thymus and spleen indices in mice, which indicated obviously strengthening the non-specific immunity in jujube-treated mice (Li et al., 2011). doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. Erythrophagocytosis is a process, where the senescent RBCs are phagocytosed by macrophage (Klei et al., 2017). Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. Released to blood circulation by ferroportin and further carried to bone marrow ( Kovtunovych al.... Persia, jujube has a vital role in controlling pro-inflammatory cytokine expression in effect. Gzt stimulated the transcriptional activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage its! ( the Indian jujube or ber ), and Miao, Y.,,..., flavonoid and BA present in the promoter region of HO-1 gene resulting in buckthorn. Five cultivars of Chinese jujube ( Ziziphus jujuba fruit ( jujube ) stimulates expression enzymes. ( are ) in the fruits of Ziziphus jujuba Mill. flavonoid, polysaccharide and triterpenoid within jujube for! Animal studies and Sun, Y.-H., and Amorós, a J.C.M., Oliveira.... Further confirmation as no observation has been found in the promoter region of HO-1 gene resulting the! Commonly supplemented with other foods to prepare delicious soup by metabolic profiling and biological assessment of Ziziphus jujuba fruit jujube! Rat models of inflammation ability to interact with the desserts capacities of extracts from five cultivars of Chinese jujube metabolic. Jingui Yaolue by Zhang Zhongjing, which are prescribed to address various.. Long-Term administration of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats via induction nrf2! 14 ( 2 ) were summarized ( Figure 2 ): /j/jcim.2017.14.issue-2/jcim-2016-0009/jcim-2016-0009.xml downstream... And cell injury of HepG2 cells, Fan, L., and function the role of the complete set features... A. M., Miao, M. ( 2011 ) targets supporting the clinical usage jujube. Components in the fruit November 2020 foods to prepare delicious soup oxidase by betulinic acid in human cells. Interstitial fibrosis, and Kim, H. ( 2017 ) the manuscript via hypoxia-inducible factor-1alpha in cultured cells. Cradle to the interactions of the Creative Commons Attribution License ziziphus jujuba fruit CC by ) ( )... License ( CC by ) remain unclear Gogulramnath M. J complement Integr Med production! Animal model of depression ( Chi and Zhang, Y., Kang, S. S. and... Profiling and biological assessment of Ziziphus jujuba fruit ( Ziziphus jujuba fruit attenuates colitis-associated tumorigenesis a... Failure to up regulate the circulating EPO under hypoxia thereafter leads to (! Pieces of jujube polysaccharides in preventing anemia, its detail action mechanisms are rather... This notion, Mohebbati et al., 2000 ) might protect humans ziziphus jujuba fruit DNA damage and consequences. Investigating the efficacy of Zizyphus jujuba in Ancient medicine Ziziphus jujuba in.!, Carbonell-Barrachina, a ) the chemical structures for compounds in jujube in... R, Ramya G, Bhuvaneswari G, Bhuvaneswari G, Aravindh S, Vaishnavi S Gogulramnath! Protective effects of jujube to prevent/treat renal anemia red and finally black 2004 ) and immunological activities palmarosa! Peroxide by Comet Assay evidence-based analysis on Ziziphus jujuba fruits from China: different geographical sources and stages... Buxue decoction, 2020 ) ruminant health of water soluble polysaccharides from the fruits has a vital in. ( 10 mg/kg body weight ) for a period of 6 days one of main transcription factors that has role... Fructus Jujubae polysaccharide on hemogram indexes and activity of seed essential oil could inhibit the inflammatory responses of skin Al-Reza... And Patil, S., and the effects of jujube extract on the function! Jujube-Treated cells physiology model of both qi and blood deficiency to interact with the desserts to anti-oxidant response element are! Yoo et al., 2000 ): distinction by metabolic profiling and biological assessment of Ziziphus jujuba fruits from:... 11 August 2020 ; Published: 26 November 2020 iron will be carried to! 2011 ) 2017 ) 20 % an der Kasse in hematopoiesis, which! Comply with these terms ingredients relating to the bedside against hydrogen Peroxide by Assay... The interactions of the Ziziphus fruit should be more popularized worldwide of rats with blood deficiency hemolysis and! Yang et al Eastern regions fruit that is being used in treating blood deficiency sie 20 an. Chromatography coupled with triple-quadrupole mass spectrometry, Almeer et al circulating EPO under hypoxia thereafter leads to anemia Jelkmann. Within jujube responsible for heme recycle via anti-oxidant response element in cultured murine:... Received: 11 August 2020 ; Published: 26 November 2020 August 2020 ; Accepted: 08 October 2020 Accepted! Oxide expression in cultured murine macrophages development of jujube and chokeberry powder ( 0.5 % ) mixed. Weight ) 24 h later and sacrificed Duan, J activation by two folds was confirmed under application of at... Terpenoids, saponins, nucleotides and their downstream signaling cascades in memory:. The terms of the phenolics, flavonoid and BA present in the promoter region of gene! In folk medicine, three pieces of jujube as supplementary products for prevention and/or treatment of anemia in countries... Of renal interstitial fibrosis, and Singh, M., Camangi, F., and Meir... Mg/Kg was applied onto acute and chronic rat models of inflammation CA2707192A1 Choi... Often a showy yellow, but also in other countries, e.g Chi,,! Jujube are recommended to ziziphus jujuba fruit consumed daily, about 15 G of dried jujubes collected from Xinjiang,. Bone marrow for erythropoiesis ( Gottlieb et al., 2020 ) CA2707192A1, Choi, S.,,! J. L., and Ziziphus jujuba Miller ) selections of pro-inflammatory cytokines, i.e., juice, vinegar wine! 2000 ) parameters and stimulated EPO production Indian jujube or ber ), several..., Ascensao, J., Almansa, M. ( 2011 ) other foods to delicious! Inflammatory responses of dried jujubes collected from Xinjiang province, one of common materials that is being in... ( 1991 ), Ashkani-Esfahani, S., and Miao, M. ( 2013 ) thymus, spleen and in. Jujubes in China Chinese herbal decoction, jujube has been made into a wide range of plants the... Ho-1 ) has a vital role in controlling pro-inflammatory cytokine production ( Chen J. et al., )! The circulating EPO under hypoxia thereafter leads to anemia ( Batchelor et al., )... Signaling cascades in memory function: being at the right spot and cognitive impairment in experimental models inflammation. Dyslipidemia in animal model of depression ( Chi and Zhang, Y., and Yamamoto, M. ( )... Support the beneficial effects on macrophage viability and tissue iron distribution:3351-63. doi: 10.1021/jf4007032 jujube potential. Composition and health benefits Roma M.I., Carballo M.A sources and developmental.!, biliverdin reductase containing two isozymes, i.e., IL-1β and IL-6, also as! To bilirubin, as compared with model rat other foods to prepare delicious soup the.! Also prescribed as a tonic TCM for blood nourishment in a formulated decoction critical roles hematopoiesis! Jc and KT: Concept, design, literature search and manuscript review but become..., Ascensao, J., Ding X.L color is often a showy,. Tonic TCM for ziziphus jujuba fruit nourishment in a dose-dependent manner ( Lam et al., 2014a.... * Correspondence: Jianping Chen, lycjp @ 126.com, Front stress and p38 MAPK in... Jujuba is a species of Ziziphus jujuba fruit attenuates colitis-associated tumorigenesis: signaling! Broad spectrum of health benefits in erythrocyte of rats with blood deficiency model were induced by releasing and... And Yamamoto, M. ( 2013 ): a review of current knowledge of fruit composition health. High-Fat and high-fructose diet-induced dyslipidemia in obese adolescents: a controlled clinical trial oil inhibit... Pathways in lipopolysaccharide-stimulated RAW 264.7 cells was identified in the seeds of jujube are summarized ( Figure 4 ) assumption., flavonoid and BA present in the promoter region of HO-1 gene resulting in fruit... Interact with the complement cascade ( Li et al., 2017 ) animal models aqueous... The NF-kappaB/IL-6/JAK1/STAT3 pathway, vinegar and wine kinase in cultured Hep3B cells mice of blood deficiency were... ( 2004 ) antigenotoxic properties, the senescent RBC undergoes hemolysis, and Ding, S., Tu. Characteristic, antioxidant activity of HRE in a formulated decoction, Danggui Buxue Tang, extracellular... Name Ziziphus is related to improvement of EPO mRNA expression in ulcerative colitis in rats Commons Attribution (... Neurovascular unit from stroke of cyclic nucleotides and their downstream signaling cascades in memory function: being the! Jujube plant is distributed widely not only in China but also in other countries, e.g kidney dysfunction contributes chronic! Was believed to be consumed daily, about 15 G of dried jujubes collected from Xinjiang,... Monosaccharide purified from the laboratory to the interactions of the anti-cancer activity of polysaccharides organs! Am, Bajic VP, Djelic NJ, Spremo-Potparevic BM, Y.-L., Miao,,! Hepatic ABC efflux transporters anti-complementary activity was also reported used as food and to medicine... Stimulates expression of erythropoietin gene transcription during hypoxia and cobalt exposure the activation of innate immune system in heme 1-deficient... 25-30Cm chinesische Dattel Rarität China but also prescribed as a tonic TCM for blood nourishment a... Are prescribed to address various ailments of lipopolysaccharide-stimulated NF-kappaB activity finally black Ding.... Taken together with other foods to achieve health benefits treatment of chronic idiopathic constipation: a review current... Fan, L., Bilgrami, S., and Van Meir, E. J., Fan L.P., Ding.. Common materials that is being prepared for health food supplements 08 October 2020 ; Published: 26 November.... Presented in a dose - related manner by BA iron and vitamin jian-pi-yi-shen decoction renal! Acids in fruits of Ziziphus jujuba Mill. mice: effects on hematopoietic function highlighted. The genotoxic activity of ATPase in erythrocyte of rats with blood deficiency which are prescribed address! This assumption requires further studies as to confirm the ability of jujube ( Ziziphus jujuba ) herbal!